Summary of ADVANTECH RELEASES HIGH-PERFORMANCE 3.5” SBC MIO-5373 WITH 8TH GEN. INTEL® CORE™ PROCESSORS
Advantech’s MIO-5373 is a compact 3.5” SBC (146 x 102 mm) powered by 8th Gen Intel Core low-power (Whiskey Lake-U) quad-core SoC. It supports up to 32GB/64GB DDR4, NVMe x4 M.2 storage, triple display (LVDS/eDP, HDMI, DisplayPort up to 4K), and hardware video codecs. Domain-focused I/O includes CANBus, high-speed RS-232/422/485, I2C, and iManager3.0 for power and system control. Flexible expansion via multiple M.2 slots, MIO Extension PCIe/USB/LPC/SMBus slots, and optional MIOe-260 I/O module suits medical, automation, kiosk, and small-form-factor industrial applications.
Parts used in the MIO-5373:
- 3.5” SBC MIO-5373 board (146 x 102 mm)
- 8th Gen Intel Core low-power SoC (Whiskey Lake-U)
- Dual-channel DDR4 memory (supports up to 32GB/64GB*)
- M.2 M-Key 2280 NVMe x4 slot (optional SATA SSD)
- M.2 E-Key slot (WiFi+BT or AI acceleration card)
- M.2 B-Key slot (3G/LTE module or SATA SSD)
- iManager3.0 embedded controller (EIO-201)
- Interfaces: LVDS/eDP, HDMI, DisplayPort
- Serial interfaces: RS-232/422/485 (up to 1 Mbps)
- I2C interface (100 kb/400 kb/1 Mb)
- CANBus interface
- MIO Extension interface (4 x PCIe x1/USB/LPC/SMBus slots)
- MIOe-260 I/O module (2 x GbE, 8 x UART, 4 x USB, 2 x isolated CANBus, miniPCIe, M.2 B-key)
- Hardware monitoring, smart fan control, watchdog timer
Advantech (2395.TW), a leading global provider of IoT systems and embedded platforms, is pleased to announce the latest 3.5” SBC MIO-5373 based on the 8th Gen. Intel Core platform with low-power SoC. Featuring compact 146 x 102mm dimensions, the MIO-5373 design not only offers impressive I/O functionality but also provides domain-focused features like CANBus and wide-ranging power input. It is ideally suited for use in application fields like medical equipment, automation control systems, outdoor kiosks, and areas requiring small-size adoption with Intel Core-level computing performance.

Quad-Core Performance and High Speed NVMe x4
The new 8th Gen. Intel Core low-power SoC (codename: Whiskey Lake-U) is the first generation to double the computing cores from dual to quad. This new generation provides double the computing performance with 15W power consumption. Featuring a built-in Gen9LP graphics engine, MIO-5373 supports three simultaneous displays through LVDS/eDP, HDMI, and DisplayPort interfaces up to 4K resolution, as well as H.265/HEVC, H.264/AVC, MPEG2 hardware decode/encode. Dual channel DDR4 supports up to 32GB/64GB* and the M.2 M-Key 2280 NVMe x4 supports high-speed PCIe SSDs to provide an extremely high data rate for computing and storage. Enhancing overall system performance—rather than just that of the core processor—makes it well-suited for image processing in medical applications and heavy loading content kiosk displays.
Domain-Focused I/O and Flexible Expansion
MIO-5373’s built-in iManager3.0 is based on Advantech’s EIO-201 embedded controller which integrates power sequence control for higher reliability and generic functions including GPIO, hardware monitoring, smart fan control, and watchdog timer. It also has domain-focused features like high-speed RS-232/422/485 up to 1Mbps, I2C (100kb/400kb/1Mb), and CANBus. iManager provides I/O functionality in company with drivers and software APIs on both the Windows and Linux operating systems to make it easier for software development. MIO-5373 provides adequate expansion for a variety of function cards, including: M.2 E-Key for WiFi+BT, or AI acceleration card; M.2 B-Key for 3G/LTE modules, or SATA SSD; and M.2 M-key NVMex4 with optional SATA SSD. What’s more, Advantech’s MIO Extension interface provides 4 x PCIe x1/USB/LPC/SMBus slots for vertically-focused or customized expansion. The MIOe-260 I/O module provides an additional 2 x GbE, 8 x UART, 4 x USB, and 2 x CANBus with isolation, miniPCIe socket, and a M.2 B-key socket. Together with MIO-5373 and MIOe-260, it enables factory automation processes for AGV, CNC machines, and medical equipment I/O requirements.
Read more: ADVANTECH RELEASES HIGH-PERFORMANCE 3.5” SBC MIO-5373 WITH 8TH GEN. INTEL® CORE™ PROCESSORS
- What processor does the MIO-5373 use?
It uses an 8th Gen Intel Core low-power SoC (Whiskey Lake-U) quad-core processor. - Can the MIO-5373 drive multiple displays?
Yes, it supports three simultaneous displays via LVDS/eDP, HDMI, and DisplayPort up to 4K. - What storage options are supported?
It supports M.2 M-Key 2280 NVMe x4 and optional SATA SSD; M.2 B-Key can also accept SATA SSD. - Does the board include domain-focused I/O like CANBus?
Yes, it includes CANBus plus high-speed RS-232/422/485 and I2C. - What expansion slots are available?
It has M.2 E-Key, M.2 B-Key, M.2 M-Key, and an MIO Extension interface with 4 x PCIe x1/USB/LPC/SMBus slots. - What is iManager3.0 and what does it provide?
iManager3.0 is based on the EIO-201 embedded controller and provides power sequence control, GPIO, hardware monitoring, smart fan control, and a watchdog timer, with drivers/APIs for Windows and Linux. - Can the MIO-5373 be used in medical and automation applications?
Yes, it is suited for medical equipment, automation control systems, outdoor kiosks, and other small-size Intel Core-level applications. - What additional I/O does the MIOe-260 module add?
The MIOe-260 adds 2 x GbE, 8 x UART, 4 x USB, 2 x isolated CANBus, a miniPCIe socket, and an M.2 B-key socket.
